| Identification | Back Directory | [Name]
DIFETHIALONE | [CAS]
104653-34-1 | [Synonyms]
LM2219
Baraki
RODILON
Hsdb 7119
GENERATION
Difethiarol
DIFETHIALONE
Difethialone-13C6
Difethialone [iso]
ro-1-naphthalenyl)-4-hydroxy-
Difethialone (Mixture of Diastereomers)
Difethialone-d4 (Mixture of Diastereomers)
2h-1-benzothiopyran-2-one,3-(3-(4’-bromo(1,1’-biphenyl)-4-yl)-1,2,3,4-tetrahyd
3-[3-[4-(4-bromophenyl)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl]-2-hydroxythiochromen-4-one
2H-1-Benzothiopyran-2-one, 3-3-(4-bromo1,1-biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl-4-hydroxy-
3-(3-(4'-Bromo(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-2H-1-benzothiapyran-2-one
3-[3-(4'-BroMo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzothiopyran-2-one
2H-1-Benzothiapyran-2-one, 3-(3-(4'-bromo(1,1'-biphenyl)-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy- | [Molecular Formula]
C31H23BrO2S | [MDL Number]
MFCD01663605 | [MOL File]
104653-34-1.mol | [Molecular Weight]
539.48 |
| Chemical Properties | Back Directory | [Melting point ]
203-227° | [Boiling point ]
658.3±55.0 °C(Predicted) | [density ]
1.3614 g/cm3(Temp: 25 °C) | [solubility ]
Chloroform: slightly soluble; Methanol: slightly soluble | [form ]
A solid | [pka]
4.50±1.00(Predicted) | [Henry's Law Constant]
9.9×100 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | [EPA Substance Registry System]
Difethialone (104653-34-1) |
| Safety Data | Back Directory | [RIDADR ]
UN2588 (Pesticide, solid, poi-
sonous, n.o.s.); UN2902 (Pesticide, liquid, poisonous,
n.o.s.) | [HS Code ]
29349990 | [Hazardous Substances Data]
104653-34-1(Hazardous Substances Data) | [Toxicity]
LD50 orally in male, female rats, mice (mg/kg): 0.62, 0.42, 0.52, 0.43 (non-resistant); 0.27, 0.39, 0.46, 0.52 (warfarin resistant); LD50 in hare: 0.75 mg/kg; LC50 in mallard duck, bobwhite quail (ppm): 1.94, 0.56; LD50 at 48 hrs in daphnia magna, bluegill sunfish, rainbow trout (mg/l): 4.4, 110, 67 (Lechevin) |
| Hazard Information | Back Directory | [Description]
Difethialone[104653-34-1], 3-[(1RS,3RS; 1RS,3SR)-3-
(4 -bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-
4-hydroxy-1-benzothiin-2-one, C31H23BrO2S, MW 539.5,
mp 233–236 ?C, is a slightly yellowish powder which
is practically insoluble in water, moderately soluble in
ethanol, methanol, hexane, acetone, readily soluble in chloroform,
dimethylformamide [9, p. 393]. | [Uses]
Difethialone is an anticoagulant rodenticide widely used to control rodent infestations. | [Uses]
Pesticide. | [Definition]
ChEBI:Difethialone is a member of benzenes, a member of naphthalenes and a ring assembly. | [Preparation]
Difethialone is made by condensation of 4-hydroxy-2H-
1-benzothiapyran-2-one with 3-(4 -bromo-4-biphenyl)-1,2,
3,4-tetrahydro-1-naphthol in acetic acid containing concentrated
sulfuric acid (62). | [Agricultural Uses]
Rodenticide, Pesticide: Introduced in 1986, this second-generation anticoagulant rodenticide (member of the hydroxy-4-benzothiopyranone family) is used to control mice and rats, including
those resistant to first-generation anticoagulants. Not approved for use in most EU countries. Approved for use
in the U.S. | [Trade name]
LM-2219®; PROTECTA RAT BAIT
STATION®; VETERAN PELLET®; VETERAN WAX
BLOCK® | [Mechanism of action]
Difethialone is an anticoagulant rodenticide that disrupts the normal blood clotting mechanisms in its target species. It works by inhibiting the enzyme Vitamin K epoxide reductase (VKORC1), which is crucial for the synthesis of blood clotting factors resulting in an increased bleeding tendency and eventually death. | [Pesticide Type]
Rodenticide |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|