| Identification | Back Directory | [Name]
4-Pentadecanone, 3-hydroxy- | [CAS]
1046789-93-8 | [Synonyms]
LAI1
LAI-1
LAI 1
Legionella autoinducer 1
Legionella autoinducer-1
4-Pentadecanone, 3-hydroxy- | [Molecular Formula]
C15H30O2 | [MOL File]
1046789-93-8.mol | [Molecular Weight]
242.4 |
| Hazard Information | Back Directory | [Description]
LAI-1 is a regulator of bacterial signaling, modulating gene regulation and cellular responses of eukaryotic cells (amoebae or macrophages) and a variety of processes including pathogen-host cell interactions. | [Uses]
3-Hydroxypentadecane-4-one (LAI-1; Legionella autoinducer-1) is a quorum sensing signaling molecule by Legionella pneumophila. 3-Hydroxypentadecane-4-one is an autoinducer, which affects the intercellular communication between bacteria through sensor kinases, LqsS, LqsT and LqsR[1]. | [References]
[1] Kessler A, et al., The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit. Environ Microbiol. 2013 Feb;15(2):646-62. DOI:10.1111/j.1462-2920.2012.02889.x |
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