| Identification | Back Directory | [Name]
Ganoderol B | [CAS]
104700-96-1 | [Synonyms]
Gaderol B
ganodermadiol
(24E)-5α-Lanosta-7,9(11),24-triene-3β,26-diol
Lanosta-7,9(11),24-triene-3,26-diol,(3b,24E)-
Lanosta-7,9(11),24-triene-3,26-diol, (3β,24E)-
(3beta,24E)-Lanosta-7,9(11),24-trien-3,26-diol
(3S,10S,13R,14R,17S)-17-[(E,2R)-7-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C30H48O2 | [MOL File]
104700-96-1.mol | [Molecular Weight]
440.7 |
| Chemical Properties | Back Directory | [Melting point ]
171-173 °C | [Boiling point ]
552.7±50.0 °C(Predicted) | [density ]
1.04±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
14.85±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Ganoderol B is a potent α-glucosidase inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC50 of 48.5 μg/mL (119.8 μM)[1]. | [Definition]
ChEBI: Ganoderol B is a tetracyclic triterpenoid that is lanosta-7,9(11),24-triene which is substituted by hydroxy groups at positions 3 and 27. It has been isolated from several Ganoderma species. It has a role as a hepatoprotective agent, an antiviral agent and a fungal metabolite. It is a 3beta-sterol, a primary allylic alcohol and a tetracyclic triterpenoid. It derives from a hydride of a lanostane. | [References]
[1] Sri Fatmawati, et al. Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum. Phytomedicine. 2011 Sep 15;18(12):1053-5. DOI:10.1016/j.phymed.2011.03.011 |
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