| Identification | Back Directory | [Name]
GSK2141795 | [CAS]
1047634-65-0 | [Synonyms]
GSK795
CS-1304
GSK2141795
Uprosertib
GSK 2141795C
Uprosertib(GSK2141795)
Uprosertib , GSK2141795C
Uprosertib (GSK-2141795,GSK795)
GSK2141795 (Uprosertib, GSK795)
Uprosertib, 98%, a potent and selective pan-Akt inhibitor
N-[(1S)-2-Amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide
2-Furancarboxamide, N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)- | [Molecular Formula]
C18H16Cl2F2N4O2 | [MDL Number]
MFCD28144686 | [MOL File]
1047634-65-0.mol | [Molecular Weight]
429.25 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:45.33(Max Conc. mg/mL);105.6(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.33(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);198.02(Max Conc. mM) | [form ]
Powder | [color ]
White to off-white | [InChI]
InChI=1S/C18H16Cl2F2N4O2/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27)/t10-/m0/s1 | [InChIKey]
AXTAPYRUEKNRBA-JTQLQIEISA-N | [SMILES]
O1C(Cl)=C(C2N(C)N=CC=2Cl)C=C1C(N[C@@H](CC1=CC=C(F)C(F)=C1)CN)=O |
| Hazard Information | Back Directory | [Uses]
Uprosertib is a potent and selective inhibitor of pan-Akt (1). Serine/threonine protein kinases, such as Akt, play important roles in cellular activities including cell survival and apoptosis. | [IC 50]
Akt3: 38 nM (IC50); Akt1: 180 nM (IC50); Akt2: 328 nM (IC50); ROCK1: 1570 nM (IC50); ROCK2: 1850 nM (IC50); CDK7: 2100 nM (IC50) |
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