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1047635-80-2

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1047635-80-2 Structure

1047635-80-2 Structure
IdentificationBack Directory
[Name]

GSK2141795 (hydrochloride)
[CAS]

1047635-80-2
[Synonyms]

CS-1303
GSK2141795 HCl
Uprosertib hydrochloride
GSK2141795 (hydrochloride)
Uprosertib (GSK2141795) HCl
Uprosertib HCl salt , GSK2141795C HCl salt
N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide
[Molecular Formula]

C18H17Cl3F2N4O2
[MDL Number]

MFCD28167770
[MOL File]

1047635-80-2.mol
[Molecular Weight]

465.71
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
Hazard InformationBack Directory
[Uses]

Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
[IC 50]

Akt3: 38 nM (IC50); Akt1: 180 nM (IC50); Akt2: 328 nM (IC50); ROCK1: 1570 nM (IC50); ROCK2: 1850 nM (IC50); CDK7: 2100 nM (IC50)
[References]

[1] Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800. DOI:10.1021/pr400455j
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