| Identification | Back Directory | [Name]
Methanone, [1,1'-biphenyl]-4-yl[4-[(5-bromo-2-methoxyphenyl)methyl]-1-piperazinyl]-, ethanedioate (1:1) | [CAS]
1047978-71-1 | [Synonyms]
AMC01
AMC-01
AMC 01
Methanone, [1,1'-biphenyl]-4-yl[4-[(5-bromo-2-methoxyphenyl)methyl]-1-piperazinyl]-, ethanedioate (1:1) | [Molecular Formula]
C27H27BrN2O6 | [MOL File]
1047978-71-1.mol | [Molecular Weight]
555.43 |
| Hazard Information | Back Directory | [Description]
AMC-01 induces the inactivation of eIF2-alpha by phosphorylation of serine residue 51 in a dose- and time-dependent manner. | [Uses]
AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB). AMC-01 inhibits apoptosis[1]. | [References]
[1] Hong MN, et al. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21(3):485-97. DOI:10.1007/s12192-016-0677-5 |
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