| Identification | Back Directory | [Name]
bengamide B | [CAS]
104947-69-5 | [Synonyms]
bengamide B
Bengamide B
DISCONTINUED
6-O-Tetradecanoylbengamide Z
(2R,3R,4S,5R,6E)-N-[(3S,6S)-6-(Tetradecanoyloxy)-1-methyl-2-oxohexahydro-1H-azepine-3-yl]-3,4,5-trihydroxy-2-methoxy-8-methyl-6-noneneamide
(2R,3R,4S,5R,6E)-3,4,5-Trihydroxy-2-methoxy-8-methyl-N-[[(3S)-hexahydro-1-methyl-2-oxo-6α-(tetradecanoyloxy)-1H-azepine]-3β-yl]-6-nonenamide
(6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide
D-gulo-Non-6-enonamide, 6,7,8,9-tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-, (6E)- | [Molecular Formula]
C32H58N2O8 | [MDL Number]
MFCD05861147 | [MOL File]
104947-69-5.mol | [Molecular Weight]
598.81 |
| Chemical Properties | Back Directory | [Boiling point ]
774.0±60.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.56±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Bengamide B is an inhibitor for NF-κB with an IC50 of 85 nM. Bengamide B inhibits LPS (HY-D1056)-induced expression of TNF-α, IL-6 and MCP-1, exhibits anti-inflammatory activity. Bengamide B exhibits antitumor efficacy (IC50 for HCT-116 is 2 nM)[1]. | [storage]
Store at -20°C | [References]
[1] Johnson TA, et al., Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg Med Chem. 2012 Jul 15;20(14):4348-55. DOI:10.1016/j.bmc.2012.05.043 |
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BOC Sciences
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https://www.bocsci.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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