| Identification | Back Directory | [Name]
TNF-α inhibitor | [CAS]
1049741-03-8 | [Synonyms]
TNF-α inhibitor
SPD304 dihydrochloride | [Molecular Formula]
C32H33ClF3N3O2 | [MDL Number]
MFCD09265259 | [MOL File]
1049741-03-8.mol | [Molecular Weight]
584.08 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 11.36 mg/mL (18.31 mM; ultrasonic and warming and heat to 60°C) | [form ]
White powder solid. | [color ]
White to off-white | [Water Solubility ]
H2O: >5mg/mL | [InChIKey]
GOZMBJCYMQQACI-UHFFFAOYSA-N | [SMILES]
Cl.Cl.CN(CCN(C)Cc1cn(-c2cccc(c2)C(F)(F)F)c3ccccc13)CC4=COc5cc(C)c(C)cc5C4=O |
| Hazard Information | Back Directory | [Uses]
TNF-alpha Inhibitor is a selective inhibitor of TNF-α. | [Biological Activity]
SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunitsdisplacing one of the trimer unitsresulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM.''Trimerization of TNF-α is essential for its biological activity. SPD304 inhibits the trimerization by interacting with Glycine 122 residue. It also inhibits the activity of Receptor activator of nuclear factor-KB ligand (RANKL) by similar interaction. | [in vivo]
SPD304 cannot be used in vivo due to its high toxicity[3]. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|