| Identification | Back Directory | [Name]
(R,R)-reboxetine (Mesylate) | [CAS]
105017-39-8 | [Synonyms]
(R,R)-FCE20124 mesylate
(R,R)-reboxetine (Mesylate)
(R)-2-((R)-(2-Ethoxyphenoxy)(phenyl)methyl)morpholine methanesulfonate
(R,R)-PNU155950E mesylate|||(R,R)-PNU155950E mesylate|||(R,R)-FCE20124 mesylate | [Molecular Formula]
C20H27NO6S | [MOL File]
105017-39-8.mol | [Molecular Weight]
409.5 |
| Hazard Information | Back Directory | [Uses]
(R,R)-Reboxetine mesylate is an antidepressant agent with great bioavailability. (R,R)-Reboxetine is the enantiomer of Reboxetine, which is a selective noradrenaline reuptake inhibitor. Reboxetine consists of (R,R) and (S,S) enantiomer, has low affinity for alpha-adrenergic and muscarinic receptors and low toxicity in animals[1][2]. | [IC 50]
α adrenergic receptor; Muscarinic Receptors | [References]
[1] Wienkers LC, et al. Cytochrome P-450-mediated metabolism of the individual enantiomers of the antidepressant agent reboxetine in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1334-40. PMID:10534319
[2] Dostert P, et al. Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor. Eur Neuropsychopharmacol. 1997 Apr;7 Suppl 1:S23-35; discussion S71-3. DOI:10.1016/s0924-977x(97)00417-3 |
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| Company Name: |
BePharm Ltd
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| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
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