| Chemical Properties | Back Directory | [Boiling point ]
824.4±65.0 °C(Predicted) | [density ]
1.71±0.1 g/cm3(Predicted) | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A solid | [pka]
13.43±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
K252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain, as well as, calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart. | [Uses]
K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM). | [References]
[1] Nakanishi, et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39(8), 1066-1071 (1986). |
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