| Identification | Back Directory | [Name]
(3-Amino-2-fluorophenyl)methanol | [CAS]
1051899-73-0 | [Synonyms]
(3-Amino-2-fluorophenyl)
3-Amino-2-fluorobenzyl alcohol
(3-Amino-2-fluorophenyl)methanol
Benzenemethanol, 3-amino-2-fluoro-
3-Amino-2-fluorobenzyl alcohol 97%
(3-Amino-2-fluorophenyl)methanol, 2-Fluoro-3-(hydroxymethyl)aniline | [Molecular Formula]
C7H8FNO | [MDL Number]
MFCD11846488 | [MOL File]
1051899-73-0.mol | [Molecular Weight]
141.14 |
| Chemical Properties | Back Directory | [Boiling point ]
272.4±25.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
14.05±0.10(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Uses]
(3-Amino-2-fluorophenyl)methanol is used as a reactant in the preparation of pyrazolylthiadiazolamine derivatives for the treatment of tuberculosis. | [Synthesis]
The general procedure for the synthesis of (3-amino-2-fluorophenyl)methanol from 2-fluoro-3-nitrobenzyl alcohol was as follows: in the presence of a Pt/C catalyst, (3-nitro-2-fluorophenyl)methanol (2.1 g, 12.28 mmol) was dissolved in AcOEt solution and the reaction was carried out by reduction for 1 h at 30 Psi hydrogen pressure. After completion of the reaction, the catalyst was removed by filtration and the solvent was evaporated to give (3-amino-2-fluorophenyl)methanol (1.64 g, 95% yield) in yellow solid form. Its NMR spectrum (DMSO-d6) data were as follows: δ 4.34 (d, 2H), 4.74 (bs, 2H), 5.12 (t, 1H), 6.59 (dd, 1H), 6.77 (ddd, 1H), 6.91 (dd, 1H). | [References]
[1] Patent: WO2008/104754, 2008, A1. Location in patent: Page/Page column 171 |
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| Company Name: |
NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245 |
| Website: |
www.novochemy.com |
| Company Name: |
SynAsst Chemical.
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021-60343070 |
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www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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