| Hazard Information | Back Directory | [Description]
M199 is a novel inhibitor of TLR3/9 activation, inducing secretion of IL-6, IL-8 and TNFalpha in human PBMCs. | [Uses]
M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response[1]. | [IC 50]
TLR3; TLR9; IL-6; IL-8 | [References]
[1] Natalija Kne?evi? Teofilovi?, et al. 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1530-1537. DOI:10.1016/j.bmcl.2017.02.048 |
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