| Identification | Back Directory | [Name]
1H-[1,4]Benzodioxino[2,3-c]pyrrole, 5-fluoro-2,3,3a,9a-tetrahydro-, hydrochloride (1:1), (3aR,9aR)- | [CAS]
105226-30-0 | [Synonyms]
GR50360
GR-50360
GR 50360
Fluparoxan HCl
Fluparoxan hydrochloride
1H-[1,4]Benzodioxino[2,3-c]pyrrole, 5-fluoro-2,3,3a,9a-tetrahydro-, hydrochloride (1:1), (3aR,9aR)- | [Molecular Formula]
C10H11ClFNO2 | [MOL File]
105226-30-0.mol | [Molecular Weight]
231.65 |
| Hazard Information | Back Directory | [Description]
Fluparoxan, also known as GR-50360; GR-50360A, is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold). It was shown to possess central α2-adrenoceptor antagonist activity after oral doses in man and was patented as an antidepressant by Glaxo in the early 1980s, but its development was discontinued when the compound failed to show a clear clinical advantage over existing therapies. | [Uses]
(3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) hydrochloride is a compound that can be used to synthesize and prevent and improve neurodevelopmental disorders[1]. | [IC 50]
α2-adrenergic receptor | [References]
[1] Ayana Alice Gibbs. Composition for use in the treatment of neurodevelopmental disorders. GB2503187A. 2012-09-14 |
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