| Identification | Back Directory | [Name]
p53-MDM2-IN-6 | [CAS]
1054506-59-0 | [Synonyms]
p53-MDM2-IN-6
Glycine, N-phenyl-, 2-[[4-(carboxymethoxy)phenyl]methylene]hydrazide | [Molecular Formula]
C17H17N3O4 | [MOL File]
1054506-59-0.mol | [Molecular Weight]
327.34 |
| Hazard Information | Back Directory | [Uses]
p53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 μg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC50 value of 10.44 μg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer[1]. | [References]
[1] Elgohary MK, et al. Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction. Bioorg Chem. 2024 Aug 28;153:107766. DOI:10.1016/j.bioorg.2024.107766 |
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