| Identification | Back Directory | [Name]
5HPP-33 | [CAS]
105624-86-0 | [Synonyms]
5HPP-33
5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 2-[2,6-bis(1-methylethyl)phenyl]-5-hydroxy- | [Molecular Formula]
C20H21NO3 | [MDL Number]
MFCD03085294 | [MOL File]
105624-86-0.mol | [Molecular Weight]
323.39 |
| Hazard Information | Back Directory | [Description]
5HPP-33 is a compound that was initially identified for its anti-angiogenic properties. It suppresses microtubule dynamics and depolymerises microtubule network by binding at vinblastine site on tubulin. It is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. | [Uses]
5HPP-33 is a thalidomide derivative with cell-proliferation inhibitory properties. | [Biochem/physiol Actions]
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM). |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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