| Identification | Back Directory | [Name]
Z-FA-FMK | [CAS]
105637-38-5 | [Synonyms]
Z-FA-FMK
Z-PHE-ALA-FMK
Z-PHE-ALA-CH2F
CATHEPSIN B, INHIBITOR
Z-FA-FLUOROMETHYLKETONE
CATHEPSIN B, INHIBITOR I
Z-PHE-ALA-FLUOROMETHYLKETONE
CASPASE INHIBITOR, NEGATIVE CONTROL
NEGATIVE CONTROL INHIBITOR FOR ICE PROTEASES
Caspase Inhibitor, Negative Control - CAS 105637-38-5 - Calbiochem
Carbamic acid, N-[(1S)-2-[[(1S)-3-fluoro-1-methyl-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester | [Molecular Formula]
C21H23FN2O4 | [MDL Number]
MFCD00883668 | [MOL File]
105637-38-5.mol | [Molecular Weight]
386.42 |
| Chemical Properties | Back Directory | [Melting point ]
125 - 127°C | [Boiling point ]
630.5±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO or DMF: 20 mM | [form ]
powder | [pka]
11.07±0.46(Predicted) | [color ]
white to off-white | [InChI]
1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27) | [InChIKey]
ASXVEBPEZMSPHB-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
Cell permeable negative control for FMK-labelled caspase inhibitors. Also an irreversible inhibitor of cathepsins B, L, and S | [Uses]
Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain. | [Biological Activity]
Z-Phe-Ala fluoromethyl ketone (Z-FA-FMK) is an inhibitor of cysteine proteasessuch as cathepsin B and L. It can also inhibit recombinant effector caspases 2-3-6and -7 and not initiator caspases 8 and -10. Z-FA-FMK plays a role in blocking nuclear factor K-light-chain-enhancer of activated B cells (NF-KB) transactivation. It exhibits therapeutic effects against rheumatoid arthritis. |
|
|