| Identification | Back Directory | [Name]
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE | [CAS]
105737-62-0 | [Synonyms]
CGP207122HCl
CGP 20712 mesylate
CGP 20712 DIHYDROCHLORIDE
CGP-20712A methanesulfonate salt
CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE
CGP-20712A methanesulfonate salt solid, >=98% (HPLC)
1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazoyl)phenoxy]-2-propanol mesylate
1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE
(+/-)-1-(2-(3-carbamoyl-4-hydroxyphenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy)-2-propanol methane sulfonate
(±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt | [Molecular Formula]
C23H25F3N4O5.CH4O3S | [MDL Number]
MFCD06798358 | [MOL File]
105737-62-0.mol | [Molecular Weight]
590.57 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: 10 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
H2O: >10mg/mL
DMSO: 100mg/mL | [InChIKey]
VFPOVCXWKBYDNF-UHFFFAOYSA-N | [SMILES]
CS(O)(=O)=O.Cn1cc(nc1-c2ccc(OCC(O)CNCCOc3ccc(O)c(c3)C(N)=O)cc2)C(F)(F)F |
| Hazard Information | Back Directory | [Uses]
CGP-20712A methanesulfonate salt has been used as a β1-adrenergic receptor antagonist in adult rat ventricular myocytes (ARVM) and rat cardiac fibroblasts. It may also be used as an antagonist for the β1-adrenergic receptor in rat bladder smooth muscles. | [Biological Activity]
Highly selective and potent β 1 -adrenoceptor antagonist (IC 50 = 0.7 nM). Displays 10,000-fold selectivity over β 2 -adrenoceptors. Also available as part of the β -Adrenoceptor Antagonist Tocriset™ . | [Biochem/physiol Actions]
CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist. | [in vitro]
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors. | [in vivo]
Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection. | [IC 50]
β adrenergic receptor |
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