| Identification | Back Directory | [Name]
pyrroxamycin | [CAS]
105888-54-8 | [Synonyms]
AL-R2081
SS-46506A
LL-F-42248α
pyrroxamycin
LL-F42248-alpha
Dioxapyrrolomycin
Antibiotic Al-R-2081
Antibiotic SS-46506A | [Molecular Formula]
C12H6Cl4N2O4 | [MDL Number]
MFCD01688460 | [MOL File]
105888-54-8.mol | [Molecular Weight]
384.001 |
| Hazard Information | Back Directory | [Description]
Dioxapyrrolomycin, a tricyclic pyrrole-containing antibiotic
isolated first from Streptomyces fumanus Sveshnikova
in the mid-1980s, displays moderate insecticidal
and acaricidal activity, but systematic structural changes
led to novel synthetic pyrrole derivatives with increased
insecticidal activity and mammalian safety (40). The natural
product and its synthetic congeners are uncouplers of
mitochondrial oxidative phosphorylation. | [Uses]
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin. | [Definition]
ChEBI: Pyrroxamycin is a benzodioxine. | [References]
[1] Pyrroxamycin, a new antibiotic taxonomy, fermentation, isolation, structure determination and biological properties |
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