| Identification | Back Directory | [Name]
2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- | [CAS]
105955-01-9 | [Synonyms]
KS 370G >=98% (HPLC)
N-caffeoyl-2-phenylethylamine
2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- | [Molecular Formula]
C17H17NO3 | [MOL File]
105955-01-9.mol | [Molecular Weight]
283.32 |
| Chemical Properties | Back Directory | [Melting point ]
154-155 °C(Solv: benzene (71-43-2); hexane (110-54-3); ethanol (64-17-5)) | [Boiling point ]
575.5±50.0 °C(Predicted) | [density ]
1.248±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.42±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker. | [Uses]
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2]. | [in vitro]
KS370G significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia._x000D_
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Reference: Mol Neurobiol. 2013 Dec;48(3):863-74. https://pubmed.ncbi.nlm.nih.gov/23801310/ | [in vivo]
The results show that KS370G significantly attenuated collagen deposition in the obstructed murine kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). KS370G significantly lowered the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b)._x000D_
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Reference: Eur J Pharmacol. 2015 Mar 5;750:1-7. https://pubmed.ncbi.nlm.nih.gov/25620133/ | [target]
KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. | [References]
[1] Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7. DOI:10.1016/j.ejphar.2015.01.020
[2] Weng YC, et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15. DOI:10.1016/j.ejphar.2012.03.029
[3] Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7. |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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