| Identification | Back Directory | [Name]
OLDA | [CAS]
105955-11-1 | [Synonyms]
ODA
OLDA
N-OLEOYLDOPAMINE
N-Oleoyldopamine (OLDA)
N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]9Z-OCTADECENAMIDE
(Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide
(9Z)-N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-9-OCTADECENAMIDE
9-Octadecenamide, N-[2-(3,4-dihydroxyphenyl)ethyl]-, (9Z)- | [Molecular Formula]
C26H43NO3 | [MDL Number]
MFCD05665144 | [MOL File]
105955-11-1.mol | [Molecular Weight]
417.62 |
| Hazard Information | Back Directory | [Uses]
N-Oleoyldopamine is a bioactive lipid found in the mammalian brain that selectively activates the transient receptor potential vanilloid type 1 (TRPV1) channel. It is also a 5-lipoxygenase inhibitor. | [Definition]
ChEBI: N-oleoyldopamine is a fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of dopamine. Synthesised in catecholaminergic neurons, it crosses the blood-brain barrier and might be considered as a carrier of dopamine into the brain. It is a transient receptor potential vanilloid type 1 (TRPV1) receptor agonist. It has a role as a TRPV1 agonist. It is a fatty amide, a secondary carboxamide, a member of catechols and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an oleic acid. | [Biological Activity]
Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC 50 = 36 nM at hVR1) with low affinity for rCB 1 receptors (K i = 1.6 μ M). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo . | [storage]
Desiccate at -20°C |
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