| Identification | Back Directory | [Name]
Palmatine chloride | [CAS]
10605-02-4 | [Synonyms]
Palmatine HCL
PALMATINE CHLORIDE
BERBERICINE CHLORIDE
PalMatin hydrochloride
PALMATINE HYDROCHLORIDE
2,3,9,10-TETRAMETHOXYPROTOBERBERINCHLORIDE
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride
Palmatine chloride
2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride | [Molecular Formula]
C21H22ClNO4 | [MDL Number]
MFCD00016656 | [MOL File]
10605-02-4.mol | [Molecular Weight]
387.86 |
| Chemical Properties | Back Directory | [Melting point ]
205℃ | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [color ]
Yellow | [InChI]
InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1 | [InChIKey]
RLQYRXCUPVKSAW-UHFFFAOYSA-M | [SMILES]
C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-] |
| Hazard Information | Back Directory | [Usage]
antibacterial, antimalarial, uterine contractant | [Description]
Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction.
The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles. | [Description]
Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities.1,2,3,4,5 It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively).1 Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner.2 In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).3 It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers.4 Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.5 | [Uses]
antibacterial, antimalarial, uterine contractant | [Uses]
Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent. | [target]
Antifection | [References]
Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975) |
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