| Identification | Back Directory | [Name]
5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)indoline | [CAS]
1062174-44-0 | [Synonyms]
INDOLIN-5-YLBORONIC ACID PINACOL ESTER
5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)indoline
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole
1H-Indole, 2,3-dihydro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- | [Molecular Formula]
C14H20BNO2 | [MDL Number]
MFCD16995801 | [MOL File]
1062174-44-0.mol | [Molecular Weight]
245.13 |
| Chemical Properties | Back Directory | [Boiling point ]
372.7±31.0 °C(Predicted) | [density ]
1.08±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
4.59±0.20(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 3: tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dihydroindole-1-carboxylate (120 mg, 0.35 mmol) was dissolved in dichloromethane (5 mL), 2,2,2-trifluoroacetic acid (1 mL) was added, and the reaction mixture was stirred for 2 hours at room temperature. After the reaction was completed, it was neutralized with saturated aqueous sodium bicarbonate solution to pH=8 and then extracted with dichloromethane. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dihydroindole (74 mg, 87% yield).1H NMR (CDCl3) δ: 7.56 (1H, s), 7.50 (1H, d, J = 8.0 Hz), 6.60 (1H, d, J = 8.0 Hz), 3.57 (2H, t, J = 8.8 Hz), 3.02 (2H, t, J = 8.8 Hz), 1.32 (12H, s). | [References]
[1] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 48 |
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