| Identification | Back Directory | [Name]
4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride | [CAS]
106261-64-7 | [Synonyms]
4-(4-Methylpiperizinomethyl)benzoylchloride2HCl
4-[(4-Methyl-1-piperazinyl)Methyl]benzoyl chloride
4-(4-Methylpiperazinylmethyl)benzoyl chloride DiHCl
4-(4-methylpiperazin-1-yl）benzoyl chloride dihydrochloride
4-(4-Methylpiperizinomethyl)benzoylchloridedihydrochloride
4-(4-METHYLPIPERAZINYLMETHYL)BENZOYL CHLORIDE DIHYDROCHLORIDE
4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochlorid...
4‐[(4‐Methyl‐1‐piperazinyl)‐methyl]‐benzoyl chloride hydrochloride
4-[(4-Methyl-1-piperazinyl)methyl]benzoyl chloride dihydrochloride
4-((4-Methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride
4-(4-Methyl piperazine-1-yl)methyl benzoyl chloride dihydrochloride
Benzoyl chloride,4-[(4-Methyl-1-piperazinyl)Methyl]-, hydrochloride (1:2) | [EINECS(EC#)]
680-808-3 | [Molecular Formula]
C13H19Cl3N2O | [MDL Number]
MFCD11519983 | [MOL File]
106261-64-7.mol | [Molecular Weight]
325.66 |
| Chemical Properties | Back Directory | [Melting point ]
>240°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
100vol% at 20℃[vol%] | [Stability:]
Hygroscopic, Moisture Sensitive |
| Hazard Information | Back Directory | [Uses]
4-((4-Methylpiperazin-1-yl)methyl)benzoyl Chloride Dihydrochloride is an intermediate in the synthesis of Gleevec N-4-((4-Methylpiperazin-1-yl)methyl)benzaldehyde (G407010), an impurity of Gleevec (G407000), a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). | [Synthesis]
Imaric acid 1g (5g, 0.021 mol, Anegi chemical) into 100mL three-necked bottle, add dichlorosulfoxide (35mL) and catalyst N, N-dimethylformamide (0.3mL), heating reflux reaction for 22 hours, reduced to room temperature, pumping and filtration, n-hexane wa |
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