| Chemical Properties | Back Directory | [Boiling point ]
512.8±45.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.04±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo[1]. | [in vivo]
DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption[1]. | Animal Model: | Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks[1] | | Dosage: | 50 mg/kg | | Administration: | Oral gavage followed 1 h later by an iron challenge | | Result: | Attenuated the post-challenge serum iron increase. |
| [storage]
Store at -20°C | [References]
[1] Cadieux JA, et, al. Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):90-5. DOI:10.1016/j.bmcl.2011.11.069 |
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