| Identification | Back Directory | [Name]
2-benzyl-6,7,8,9-tetrahydro-5H-pyriMido[4,5-d]azepine | [CAS]
1065110-62-4 | [Synonyms]
PF3246799
PF-3246799
PF 3246799
PF-03246799
2-benzyl-6,7,8,9-tetrahydro-5H-pyriMido[4,5-d]azepine
6,7,8,9-Tetrahydro-2-(phenylmethyl)-5H-pyrimido[4,5-d]azepine | [Molecular Formula]
C15H17N3 | [MDL Number]
MFCD20040357 | [MOL File]
1065110-62-4.mol | [Molecular Weight]
239.32 |
| Hazard Information | Back Directory | [Uses]
PF-03246799 (PF-3246799) is a potent and selective 5-HT2C receptor agonist with an EC50 of 190 nM and a Ki of 160 nM. PF-03246799 shows selectivity for 5-HT2C over 5-HT2A and 5-HT2B receptors. PF-03246799 has the potential for stress urinary incontinence (SUI) research[1]. | [IC 50]
5-HT2C Receptor: 190 nM (EC50); 5-HT2C Receptor: 160 nM (Ki) | [References]
[1] Andrews MD, et al. Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. DOI:10.1016/j.bmcl.2010.11.120 |
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| Company Name: |
Matrix Scientific
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| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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