| Identification | Back Directory | [Name]
Benzamide, N-[4-(1-cyano-1-methylethyl)phenyl]-3,4-dimethoxy- | [CAS]
1067189-44-9 | [Synonyms]
ADX61623
Benzamide, N-[4-(1-cyano-1-methylethyl)phenyl]-3,4-dimethoxy- | [Molecular Formula]
C19H20N2O3 | [MOL File]
1067189-44-9.mol | [Molecular Weight]
324.37 |
| Chemical Properties | Back Directory | [Boiling point ]
434.3±45.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.80±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ADX61623 is a potent follicle stimulating hormone (FSH) receptor (FSHR) negative allosteric modulator (NAM). ADX61623 shows luteinizing hormone receptor (LH-R) activity and is not active on thyroid-stimulating hormone (TSH) receptors. ADX61623 can be used for the study of estrogen dependent disease[1]. | [References]
[1] James A Dias, et al. A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor. Mol Cell Endocrinol. 2011 Feb 20;333(2):143-50. DOI:10.1016/j.mce.2010.12.023 |
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