| Hazard Information | Back Directory | [Description]
AZD4619 is a potent, selective and reversible orally bioavailable PPARα receptor agonist. | [Uses]
AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug[1][2]. | [IC 50]
PPARα | [References]
[1] Petra Thulin, et al. PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008 Aug 15;231(1):1-9. DOI:10.1016/j.taap.2008.03.007
[2] Petra Thulin, et al. The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels. Int J Mol Med. 2016 Sep;38(3):961-8. DOI:10.3892/ijmm.2016.2681 |
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