| Identification | Back Directory | [Name]
N-Methyl Naltrexone Glucuronide | [CAS]
1067644-15-8 | [Synonyms]
Methylnaltrexone Glucuronide
N-Methyl Naltrexone Glucuronide | [Molecular Formula]
C27H34NO10+ | [MOL File]
1067644-15-8.mol | [Molecular Weight]
532.57 |
| Hazard Information | Back Directory | [Uses]
N-Methyl Naltrexone Glucuronide is metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. |
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