| Identification | Back Directory | [Name]
1H-INDOLE-2,4-DIONE, 3-[2,5-DIHYDRO-3-METHYL-5-OXO-1-[4-(TRIFLUOROMETHOXY)PHENYL]-1H-PYRAZOL-4-YL]-3,5,6,7-TETRAHYDRO-6,6-DIMETHYL-1-PHENYL-3-(TRIFLUOROMETHYL)- | [CAS]
1067647-43-1 | [Synonyms]
ELOVL6-IN-2
6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrzol-4-yl)-1-ph
6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyr zol-4-yl)-1-phen
ELOVL6IN2,ELOVL6 IN 2,plasma,inhibit,selective,ELOVL-6-IN-2,liver,dose-proportionally,Inhibitor,potent,orally
6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrzol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-1H-indole-2,4(3H,5H)-dione
6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-1H-indole-2,4(3H,5H)-dione
1H-INDOLE-2,4-DIONE, 3-[2,5-DIHYDRO-3-METHYL-5-OXO-1-[4-(TRIFLUOROMETHOXY)PHENYL]-1H-PYRAZOL-4-YL]-3,5,6,7-TETRAHYDRO-6,6-DIMETHYL-1-PHENYL-3-(TRIFLUOROMETHYL)- | [Molecular Formula]
C28H23F6N3O4 | [MDL Number]
MFCD18782631 | [MOL File]
1067647-43-1.mol | [Molecular Weight]
579.49 |
| Chemical Properties | Back Directory | [Boiling point ]
609.6±65.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO : 100 mg/mL (172.57 mM; Need ultrasonic) | [form ]
Solid | [pka]
-1.24±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM[1]. | [in vivo]
ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver[1].
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable[1].
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure[1]. | Animal Model: | Male C57BL/6J mice | | Dosage: | 0.1~1mg/kg | | Administration: | P.o | | Result: | Potently and dose-proportionally suppressed the elongation index in the liver.
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| Animal Model: | Male C57BL/6J mice | | Dosage: | 10 mg/kg | | Administration: | P.o | | Result: | Demonstrated highly liver penetrable.
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| Animal Model: | Male C57BL/6J mice | | Dosage: | 1 mg/kg | | Administration: | P.o | | Result: | Exhibited sustained plasma exposure.
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| [References]
[1] akahashi T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145. DOI:10.1021/jm900391x |
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| Company Name: |
Matrix Scientific
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803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
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