| Identification | Back Directory | [Name]
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE | [CAS]
106877-29-6 | [Synonyms]
5-METHYL-2-(TRIFLUOROMETHYL)ANILINE
5-Methyl-2-trifluoromethyl-phenylamine
5-Methyl-2-(trifluoromethyl)aniline,98%
Benzenamine, 5-methyl-2-(trifluoromethyl)- | [Molecular Formula]
C8H8F3N | [MDL Number]
MFCD04972928 | [MOL File]
106877-29-6.mol | [Molecular Weight]
175.15 |
| Chemical Properties | Back Directory | [Boiling point ]
207.2±35.0 °C(Predicted) | [density ]
1.237±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [pka]
1.59±0.10(Predicted) | [Appearance]
Yellow to brown Liquid | [Water Solubility ]
Slightly soluble in water. |
| Hazard Information | Back Directory | [Synthesis]
Step 1: 4-methyl-2-nitro-1-trifluoromethylbenzene (1 g, 4.8 mmol) and 30 mL of methanol were added to a 100 mL reaction vial. Pd/C catalyst (0.2 g, 10% content) was then added. The reaction mixture was stirred under hydrogen atmosphere (1 atm, 25°C) for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/petroleum ether = 1:10) to afford 2-amino-4-methylbenzotrifluoride (0.68 g, 80% yield). Mass spectrometry analysis: [M+1]+ 176.2. | [References]
[1] Patent: EP3150592, 2017, A1. Location in patent: Paragraph 0133; 0134; 0135
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3738 - 3743 |
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| Company Name: |
Alfa Aesar
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| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
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