| Identification | Back Directory | [Name]
L-LEUCINE-2,3,3,4,5,5,5,6,6,6-D10 | [CAS]
106972-44-5 | [Synonyms]
15N, 97%)
L-LEUCINE-D10
l-leucine-c-d10
L-LEUCINE (D10, 98%)
L-LEUCINE-2,3,3,4,5,5,5,6,6,6-D10
L-Leucine-2,3,3,4,5,5,5,5′,5′,5′-d10
L-Leucine-2,3,3,4,5,5,5,5′,5′,5′-d??
L-LEUCINE-2,3,3,4,5,5,5,6,6,6-D10, 98 AT OM % D
L-Leucine-2,3,3,4,5,5,5,5',5',5'-d10 98 atom % D | [Molecular Formula]
C6H3D10NO2 | [MDL Number]
MFCD01321412 | [MOL File]
106972-44-5.mol | [Molecular Weight]
141.23 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C(lit.) | [storage temp. ]
Refrigerator | [solubility ]
Aqueous Acid (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [optical activity]
[α]25/D +14.5°, c = 2 in 5 M HCl |
| Hazard Information | Back Directory | [Uses]
L-Leucine-d10 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857. DOI:10.1371/journal.pgen.1003857
[3] Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77. DOI:10.1186/1743-7075-9-77
[4] Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17. DOI:10.2337/db11-0765 |
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