| Identification | Back Directory | [Name]
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine | [CAS]
1071098-42-4 | [Synonyms]
N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
N2,N?-bis(2-Methyl-1H-indol-5-yl)pyrimidine-2,4-diamine | [Molecular Formula]
C22H20N6 | [MOL File]
1071098-42-4.mol | [Molecular Weight]
368.43 |
| Chemical Properties | Back Directory | [Boiling point ]
711.0±70.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
Solid | [pka]
17.48±0.30(Predicted) | [color ]
Light brown to brown | [InChI]
1S/C22H20N6/c1-13-9-15-11-17(3-5-19(15)24-13)26-21-7-8-23-22(28-21)27-18-4-6-20-16(12-18)10-14(2)25-20/h3-12,24-25H,1-2H3,(H2,23,26,27,28) | [InChIKey]
SYWHWWKOIJCMKF-UHFFFAOYSA-N | [SMILES]
CC1=CC2=C(N1)C=CC(=C2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)NC(=C5)C |
| Hazard Information | Back Directory | [Description]
AZA1 is a Rac1/Cdc42 GTPase-specific inhibitor which suppresses prostate cancer. | [Uses]
AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2]. | [in vivo]
AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival[1]. | Animal Model: | 5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)[1] | | Dosage: | 100 μg in 100 μl 30% DMSO | | Administration: | I.p.; daily for 2 weeks | | Result: | The suppressive effect of AZA1 on tumor growth was significant.
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| [References]
[1] Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):e74924. Published 2013 Sep 11. DOI:10.1371/journal.pone.0074924
[2] Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091‐2099. DOI:10.3892/ijo.2015.3211 |
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| Company Name: |
Struchem Co., Ltd.
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| Tel: |
0512-63009836 18994340901 |
| Website: |
www.beidapharma.com |
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