| Identification | Back Directory | [Name]
L-Proline, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl- | [CAS]
1071173-56-2 | [Synonyms]
SN52
L-Proline, L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl- | [Molecular Formula]
C128H230N38O28 | [MOL File]
1071173-56-2.mol | [Molecular Weight]
2749.43 |
| Hazard Information | Back Directory | [Uses]
SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research[1]. | [in vivo]
SN52 (intrathecal injection; 40 μg/ml; day-1, day 1 and day 3 of 20Gy radiation of radiation) combines with IR enhances anti-tumor immune functions of both DCs and CD8+?T cells and subsequently reduced tumor burden more effectively compared with IR alone[1]. | Animal Model: | Tumor mice model[1] | | Dosage: | 40 μg | | Administration: | Intrathecal injection; 40 μg; day-1, day 1 and day 3 of 20Gy radiation of radiation | | Result: | Reduced tumor burden than IR group alone.
Induced non-canonical NF-κB inhibition and potentiates the anti-tumor effect of IR.
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| [References]
[1] Yong Xu, et al. SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther DOI:10.1158/1535-7163.MCT-08-0238
[2] Yuzhu Hou, et al. Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Immunity. 2018 Sep 18;49(3):490-503.e4 DOI:10.1016/j.immuni.2018.07.008 |
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Fuan Bio
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15002819872 |
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fuanbio.com / www.fuanbio.com |
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