| Identification | Back Directory | [Name]
3,5-Dichloro-N-[[4-fluoro-1-[[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]methyl]-4-piperidinyl]methyl]Benzamide | [CAS]
1072018-68-8 | [Synonyms]
TTA-P2
T-Type Ca2+ channel inhibitor
T-Type calcium channel inhibitor(TTA-P2)
(S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)m
(S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)meth
3,5-DICHLORO-N-[1-(2,2-DIMETHYL-TETRAHYDRO-PYRAN-4-YLMETHYL)-4-FLUORO-PIPERIDIN-4-YLMETHYL]-BENZAMIDE
(S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide
3,5-Dichloro-N-[[4-fluoro-1-[[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]methyl]-4-piperidinyl]methyl]Benzamide
BenzaMide, 3,5-dichloro-N-[[4-fluoro-1-[[(4S)-tetrahydro-2,2-diMethyl-2H-pyran-4-yl]Methyl]-4-piperidinyl]Methyl]- | [Molecular Formula]
C21H29Cl2FN2O2 | [MDL Number]
MFCD14636429 | [MOL File]
1072018-68-8.mol | [Molecular Weight]
431.37 |
| Chemical Properties | Back Directory | [Boiling point ]
510.1±50.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.65±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease[1]. | [References]
[1] Chemin J, et al. De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene. Brain. 2018;141(7):1998-2013. DOI:10.1093/brain/awy145 |
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Alomone Labs
|
| Tel: |
4008-168-068 13121892008 |
| Website: |
www.alomone.com |
| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
|