| Identification | Back Directory | [Name]
N-[3-(4,5-DIHYDRO-2-THIAZOLYL)-2-THIAZOLIDINYLIDENE]-5H DIBENZO[A,D] CYCLOHEPTEN-5-AMINE | [CAS]
1072145-33-5 | [Synonyms]
1072145-33-5
ERRα antagonist 1
N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine
N-[3-(4,5-DIHYDRO-2-THIAZOLYL)-2-THIAZOLIDINYLIDENE]-5H DIBENZO[A,D] CYCLOHEPTEN-5-AMINE
5H-Dibenzo[a,d]cyclohepten-5-amine, N-[3-(4,5-dihydro-2-thiazolyl)-2-thiazolidinylidene]-
N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine 97% | [Molecular Formula]
C21H19N3S2 | [MDL Number]
MFCD17676143 | [MOL File]
1072145-33-5.mol | [Molecular Weight]
377.53 |
| Chemical Properties | Back Directory | [Boiling point ]
579.0±60.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Solid | [pka]
4.98±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1]. | [IC 50]
ERRα | [References]
[1] Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related |
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Energy Chemical
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http://www.energy-chemical.com |
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cjbscvictory
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