| Identification | Back Directory | [Name]
Cevimeline Hydrochloride Salt | [CAS]
107220-28-0 | [Synonyms]
Fks 508
SNK 508
Saligren
Snd 5008
CeviMelin
rac-Cevimeline HCl
AF-102B hydrochloride
SNI-2011 hydrochloride
Cevimelin Hydrochloride
CEVIMELINE, HYDROCHLORIDE SALT
CeviMeline hydrochloride Saligren
rac,cis-Cevimeline Hydrochloride Salt
AF-102B HYDROCHLORIDE;SNI-2011 HYDROCHLORIDE
cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]hydrochloride
2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane],hydrochloride
(2'R,3R)-rel-2'-Methyl- spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] hydrochloride | [Molecular Formula]
C10H18ClNOS | [MDL Number]
MFCD01961045 | [MOL File]
107220-28-0.mol | [Molecular Weight]
235.774 |
| Chemical Properties | Back Directory | [Melting point ]
195-197?C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM) | [form ]
A crystalline solid | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A novel muscarinic M1 and M3 receptor agonist. Sialagogue. | [Biological Activity]
Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo . | [in vivo]
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1]. | Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II[1] | | Dosage: | 0.008 mg/kg, 0.016 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
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| [IC 50]
mAChR1; mAChR3 | [storage]
-20°C |
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