| Identification | Back Directory | [Name]
Atorvastatin strontium | [CAS]
1072903-92-4 | [Synonyms]
Atorvastatin strontium
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, strontium salt (2:1), (βR,δR)- | [Molecular Formula]
C33H35FN2O5.1/2Sr | [Molecular Weight]
602.45 |
| Hazard Information | Back Directory | [Uses]
Strontium atorvastatin is a cholesterol-lowering drug with activity in ameliorating cardiovascular disease-related events. Strontium atorvastatin exerts its biological activity by inhibiting HMG-CoA reductase in liver tissue. Strontium atorvastatin is also used to suppress dyslipidemia[1]. | [References]
[1] Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. DOI:10.1038/sj.bjp.0706836
[2] Systemic drugs with impact on osteoarthritis DOI:10.1080/03602532.2019.1687511
[3] Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. DOI:10.1097/FJC.0b013e318123767f
[4] Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. DOI:10.1161/01.atv.15.5.678
[5] Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. DOI:10.7150/ijms.8.564
[6] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. DOI:10.1371/journal.pone.0174821
[7] Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415. DOI:10.1080/01913123.2018.1522406 |
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