| Identification | Back Directory | [Name]
Rho Kinase Inhibitor V | [CAS]
1072906-02-5 | [Synonyms]
Rho Kinase Inhibitor V
Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem
1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(1H-pyrazol-4-yl)phenyl]- | [Molecular Formula]
C18H15N3O3 | [MDL Number]
MFCD28138106 | [MOL File]
1072906-02-5.mol | [Molecular Weight]
321.33 |
| Chemical Properties | Back Directory | [Boiling point ]
638.4±55.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
ethanol: 2mg/mL
DMSO: 50mg/mL | [form ]
Light beige solid | [pka]
12.53±0.70(Predicted) | [color ]
light beige | [InChI]
1S/C18H15N3O3/c22-18(17-11-23-15-3-1-2-4-16(15)24-17)21-14-7-5-12(6-8-14)13-9-19-20-10-13/h1-10,17H,11H2,(H,19,20)(H,21,22) | [InChIKey]
MCQBNMPALTYSES-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
Feng, Y., et al. 2008. J. Med. Chem.51, 6642.
A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC50 = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC50 = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC50 = 0.186, 1.19, and 1.41 µM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 µM = 87/40/1/20, respectively) only at much higher concentrations. | [General Description]
A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC50 = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC50 = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC50 = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations. |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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