| Identification | Back Directory | [Name]
PD 138312 | [CAS]
107334-06-5 | [Synonyms]
PD 138312
7-[3-(2-aminopropan-2-yl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid | [Molecular Formula]
C19H23FN4O3 | [MOL File]
107334-06-5.mol | [Molecular Weight]
374.41 |
| Hazard Information | Back Directory | [Description]
PD 138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a cyclopropyl or a difluorophenyl substitution at the 1 positions, respectively. It has been demonstrated to have excellent in vitro activity against gram-positive organisms. This compound was evaluated for its in vivo potencies against acute systemic infections in mice and in a mouse pneumococcal pneumonia model. Most remarkable was its comparative median protective value against methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes. PD 138312 has excellent therapeutic potential against clinically important gram-positive pathogens when the drugs are administered both orally and parenterally. | [Uses]
(Rac)-PD 138312 is the racemate of PD 138312. PD 138312 is a potent and orally active antibacterial agent against Gram-positive bacteria[1]. | [References]
[1] Shapiro MA, et al. In vivo therapeutic efficacies of PD 138312 and PD 140248, two novel fluoronaphthyridines with outstanding gram-positive potency. Antimicrob Agents Chemother. 1995 Oct;39(10):2183-6. DOI:10.1128/AAC.39.10.2183 |
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BOC Sciences
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16314854226 |
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www.bocsci.com |
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