| Identification | Back Directory | [Name]
CID24856225 | [CAS]
1073529-41-5 | [Synonyms]
ABL127
ML174)
CID24856225
ABL127
(AB L127
ABL127 >=98% (HPLC)
(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate
4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174)
(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester
1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)- | [Molecular Formula]
C17H20N2O5 | [MDL Number]
MFCD28053514 | [MOL File]
1073529-41-5.mol | [Molecular Weight]
332.35 |
| Chemical Properties | Back Directory | [Boiling point ]
422.8±48.0 °C(Predicted) | [density ]
1.330±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥5mg/mL | [form ]
film | [pka]
-3.45±0.40(Predicted) | [color ]
colorless | [InChI]
1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1 | [InChIKey]
ZRHWCAFAIHTQKD-KRWDZBQOSA-N | [SMILES]
O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O |
| Hazard Information | Back Directory | [Uses]
ABL127, is a selective and covalent inhibitor of protein methylesterase 1 (PME-1). | [Biological Activity]
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration. | [in vivo]
No significant decrease in tumor burden can be assessed in these pilot studies[1]. Gel-based profiles indicate that brain PME-1 is inactivated by ABL127, but overlapping serine hydrolase activities preclude a confident assessment of the extent of inactivation[2]. |
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Sigma-Aldrich
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Energy Chemical
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Merck KGaA
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