| Identification | Back Directory | [Name]
RBTNL2 | [CAS]
107401-70-7 | [Synonyms]
DAT1
LMO3
RBTN3
DIDO1
RBTNL2
MGC26081
KIAA0333
Rhombotin-3
LIM domain only protein 3
ANTI-LMO3 antibody produced in mouse
Death associated transcription factor 1
Neuronal-specific transcription factor DAT1
Anti-LMO3, C-Terminal antibody produced in rabbit
Anti-DIDO1, N-Terminal antibody produced in rabbit | [Molecular Formula]
C17H15N3O2S | [MDL Number]
MFCD03730224 | [MOL File]
107401-70-7.mol | [Molecular Weight]
325.39 |
| Hazard Information | Back Directory | [Uses]
DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization[1]. | [References]
[1] Suparna Sengupta, et al. 4-Amino-5-benzoyl-2-(4-methoxyphenylamino)thiazole (DAT1): a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145(8):1076-83. DOI:10.1038/sj.bjp.0706276
[2] Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13(1):179-89. DOI:10.1158/1535-7163.MCT-13-0479 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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