| Identification | Back Directory | [Name]
Lintopride | [CAS]
107429-63-0 | [Synonyms]
Lintopride
Benzamide, 4-amino-5-chloro-N-[(1-ethyl-4,5-dihydro-1H-imidazol-2-yl)methyl]-2-methoxy- | [Molecular Formula]
C14H19ClN4O2 | [MOL File]
107429-63-0.mol | [Molecular Weight]
310.78 |
| Chemical Properties | Back Directory | [Boiling point ]
494.1±45.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.20±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Lintopride, a benzamide, is a potent 5HT-4 antagonist with moderate 5HT-3 antagonist properties. Lintopride increases gastric emptying, stimulates antral and duodenal motility and accelerates intestinal transit in animal. Lintopride significantly increases the lower oesophageal sphincter (LOS) basal tone[1]. | [Biological Activity]
Lintopride is a 5HT4 antagonist with a slight antagonistic effect on 5HT3. | [in vitro]
Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride. | [target]
| 5-HT 4 Receptor | 5-HT 3 Receptor | | [IC 50]
5-HT4 Receptor; 5-HT3 Receptor | [storage]
Store at -20°C | [References]
[1] Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DOI:10.1111/j.1365-2036.1995.tb00422.x |
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