| Identification | Back Directory | [Name]
moflomycin | [CAS]
107430-03-5 | [Synonyms]
F860191
F-860191
F 860191
moflomycin
5,12-Naphthacenedione, 7-[(2,6-dideoxy-2-iodo-α-L-mannopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxymethyl)-, (7S,9S)- (9CI) | [Molecular Formula]
C25H25IO10 | [MDL Number]
MFCD00903770 | [MOL File]
107430-03-5.mol | [Molecular Weight]
612.37 |
| Hazard Information | Back Directory | [Uses]
Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC50=2.9 nM)[1]. Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production[2]. | [References]
[1] Andrivon W, et al. A new anthracycline with potent antileukemic activity exhibits reduced mutagenicity[J]. Mutation Research/Genetic Toxicology, 1995, 344(3-4): 135-140. DOI:10.1016/0165-1218(95)00052-6
[2] Andrivon W, et al. Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity. Leuk Res. 1996 Feb;20(2):119-26. DOI:10.1016/0145-2126(95)00155-7 |
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