| Identification | Back Directory | [Name]
COMU | [CAS]
1075198-30-9 | [Synonyms]
COMU(R) 97%
elagolix intermediate 13
COMU ISO 9001：2015 REACH
COMU NOVABIOCHEM(R) 25 G
{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}-4-morpholinomethylene}dimethylammonium
[[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate
1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate
4-(6-Cyano-2-methyl-7-oxo-4,8-dioxa-2,5-diazadec-5-en-3-ylidene)morpholin-4-ium hexafluorophosphate
{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosp
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium(COMU?)
COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium,98%
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate (This product is only available in Japan.) | [EINECS(EC#)]
682-899-5 | [Molecular Formula]
C12H19N4O4.PF6 | [MDL Number]
MFCD11975052 | [MOL File]
1075198-30-9.mol | [Molecular Weight]
428.268 |
| Chemical Properties | Back Directory | [Melting point ]
ca 160℃ | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMF 1mmol in 2mL. | [form ]
Powder or Solid | [color ]
White to pale yellow | [Sensitive ]
Air & Moisture Sensitive | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-; | [InChIKey]
GPDHNZNLPKYHCN-DZOOLQPHSA-N | [SMILES]
C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F |
| Hazard Information | Back Directory | [Description]
COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1]. | [Uses]
(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible. | [General Description]
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information. | [reaction suitability]
reaction type: Coupling Reactions | [References]
[1] Ayman El-Faham, Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.
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