| Identification | Back Directory | [Name]
2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide | [CAS]
107522-19-0 | [Synonyms]
2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide
N-[2-(5-chloro-2-nitrophenylthio)phenyl]acetamide
Acetamide, N-[2-[(5-chloro-2-nitrophenyl)thio]phenyl]-
2 Acetamidophenyl 5 chloro 2 nitrophenyl sulfide,2Acetamidophenyl 5chloro2nitrophenyl sulfide | [Molecular Formula]
C14H11ClN2O3S | [MOL File]
107522-19-0.mol | [Molecular Weight]
322.77 |
| Chemical Properties | Back Directory | [Boiling point ]
494.3±45.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
14.40±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is a sulfide-like inhibitor of phosphodiesterase 7 (PDE7; IC50 = 2.1 μM). It is selective for PDE7A, producing only 10-11% inhibition of PDE3A, PDE4D, and PDE4B at 10 μM. It also has no antioxidant activity or inhibitory activity against a panel of protein kinases. Sulfide-like PDE7 inhibitors derived from 2-acetamidophenyl 5-chloro-2-nitrophenyl sulfide have cytoprotective and anti-inflammatory effects on SH-SY5Y neuroblastoma cells without action in a surrogate emesis mouse model. | [References]
[1] ANA M. GARCíA. Modulation of cAMP-Specific PDE without Emetogenic Activity: New Sulfide-Like PDE7 Inhibitors[J]. Journal of Medicinal Chemistry, 2014, 57 20: 8590-8607. DOI: 10.1021/jm501090m |
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