| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy- | [CAS]
107585-69-3 | [Synonyms]
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-3-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy- | [Molecular Formula]
C18H18O7 | [MOL File]
107585-69-3.mol | [Molecular Weight]
346.33 |
| Hazard Information | Back Directory | [Description]
Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells. | [Uses]
Cremastranone is an antiangiogenic homoisoflavone. Cremastranone can inhibit HUVECs cell proliferation, with a GI50 value of 1.5 uM[1]. | [Definition]
ChEBI: Cremastranone is a homoisoflavonoid that is 2,3-dihydro-4H-chromen-4-onethat is substituted by hydroxy groups at positions 5 and 7, a methoxy group at position 6, and a 3-hydroxy-4-methoxybenzyl group at position 3. It has been isolated from various plants, including the bulb of Cremastra appendiculata. It has a role as a plant metabolite and an angiogenesis modulating agent. It is a homoisoflavonoid, an aromatic ether and a polyphenol. | [References]
[1] Lee B, et al. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. Org Biomol Chem. 2014 Oct 21;12(39):7673-7. DOI:10.1039/c4ob01604a |
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