| Identification | Back Directory | [Name]
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile | [CAS]
1076225-27-8 | [Synonyms]
PF 998425
PF-0998425
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
Benzonitrile, 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-
rel-(-)-4-[(1R,2R)-2-Hydroxycyclohexyl]-2-(trifluoroMethyl)benzonitrile | [Molecular Formula]
C14H14F3NO | [MDL Number]
MFCD17215970 | [MOL File]
1076225-27-8.mol | [Molecular Weight]
269.26 |
| Chemical Properties | Back Directory | [Boiling point ]
365.2±42.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [pka]
14.84±0.40(Predicted) | [color ]
white to off-white | [InChI]
1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1 | [InChIKey]
MENRRRXHFQYXDW-DGCLKSJQSA-N | [SMILES]
O[C@@H]1CCCC[C@@H]1c2ccc(C#N)c(c2)C(F)(F)F |
| Hazard Information | Back Directory | [Uses]
PF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. | [Biological Activity]
PF-998425 is a novelnonsteroidal androgen receptor antagonist. | [in vivo]
PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (μL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h[1]. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|