| Identification | Back Directory | [Name]
CW0134 | [CAS]
1076235-18-1 | [Synonyms]
CW0134
1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-methyl- | [Molecular Formula]
C11H7ClF3N3O2 | [MOL File]
1076235-18-1.mol | [Molecular Weight]
305.64 |
| Chemical Properties | Back Directory | [Boiling point ]
383.7±52.0 °C(predicted) | [density ]
1.628±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
-1.22±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1]. | [References]
[1] Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25. DOI:10.1038/s41589-024-01586-5 |
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