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107648-79-3

107648-79-3 Structure

107648-79-3 Structure
IdentificationBack Directory
[Name]

Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride (1:1)
[CAS]

107648-79-3
[Synonyms]

Cefepime chloride
Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride (1:1)
[Molecular Formula]

C19H25ClN6O5S2
[MOL File]

107648-79-3.mol
[Molecular Weight]

517.02
Hazard InformationBack Directory
[Uses]

Cefepime (BMY-28142) chloride is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime chloride shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime chloride induces neurotoxicity[1][2][3][4].
[in vivo]

Cefepime chloride (80 mg/kg; i.p.) significantly increases the half-life and mice surviveed[4].

Animal Model:Male CD-1 mice[4]
Dosage:80 mg/kg
Administration:I.p.
Result:Significantly prolonged the half-life of cefepime and all mice survived at 18-22 mg/kg cisplatin, and when pretreatment with 26 mg/kg cisplatin significantly decreased survival with the half-life of cefepime was not significantly longer than of 18 mg/kg cisplatin.
[IC 50]

β-lactam
[References]

[1] Yahav D, et al. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007 May;7(5):338-48. DOI:10.1016/S1473-3099(07)70109-3
[2] Barradell LB, Bryson HM. Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994;47(3):471-505. DOI:10.2165/00003495-199447030-00007
[3] Payne LE, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care. 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. DOI:10.1186/s13054-017-1856-1
[4] Máthé A, et al. The effect of different doses of cisplatin on the pharmacokinetic parameters of cefepime in mice. Lab Anim. 2006 Jul;40(3):296-300. DOI:10.1258/002367706777611514
107648-79-3 suppliers list
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