| Identification | Back Directory | [Name]
Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride (1:1) | [CAS]
107648-79-3 | [Synonyms]
Cefepime chloride Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, chloride (1:1) | [Molecular Formula]
C19H25ClN6O5S2 | [MOL File]
107648-79-3.mol | [Molecular Weight]
517.02 |
| Hazard Information | Back Directory | [Uses]
Cefepime (BMY-28142) chloride is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime chloride shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime chloride induces neurotoxicity[1][2][3][4]. | [in vivo]
Cefepime chloride (80 mg/kg; i.p.) significantly increases the half-life and mice surviveed[4]. | Animal Model: | Male CD-1 mice[4] | | Dosage: | 80 mg/kg | | Administration: | I.p. | | Result: | Significantly prolonged the half-life of cefepime and all mice survived at 18-22 mg/kg cisplatin, and when pretreatment with 26 mg/kg cisplatin significantly decreased survival with the half-life of cefepime was not significantly longer than of 18 mg/kg cisplatin. |
| [IC 50]
β-lactam | [References]
[1] Yahav D, et al. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007 May;7(5):338-48. DOI:10.1016/S1473-3099(07)70109-3 [2] Barradell LB, Bryson HM. Cefepime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994;47(3):471-505. DOI:10.2165/00003495-199447030-00007 [3] Payne LE, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care. 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. DOI:10.1186/s13054-017-1856-1 [4] Máthé A, et al. The effect of different doses of cisplatin on the pharmacokinetic parameters of cefepime in mice. Lab Anim. 2006 Jul;40(3):296-300. DOI:10.1258/002367706777611514 |
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