| Identification | Back Directory | [Name]
2,6-Piperidinedione,3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (3S)- | [CAS]
107657-57-8 | [Synonyms]
2,6-Piperidinedione,3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (3S)- | [Molecular Formula]
C13H12N2O3 | [MOL File]
107657-57-8.mol | [Molecular Weight]
244.246 |
| Hazard Information | Back Directory | [Uses]
(S)-Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S)-Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation[1]. | [IC 50]
Cereblon | [References]
[1] Robert Luo, et al. Glutarimide-containing pan-kras-mutant degrader compounds and uses thereof. WO2024118966A1. 2023-11-30. |
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